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ea0099ep244 | Pituitary and Neuroendocrinology | ECE2024

CTGF expression in human pituitary tumors and its association with their aggressiveness: preliminary data from an ongoing study

Vamvoukaki Rodanthi , Kyriakopoulos Georgios , Ntali Georgia , Vassiliadi Dimitra , Vlachou Panagiota , Koukoula Chrysoula , Barkas Konstantinos , Gkalonakis Ioannis , Tzanela Marinella , Andoniadou Cynthia , Xekouki Paraskevi

Background/Aim: Pituitary neuroendocrine tumors (PitNETs), although usually indolent, may display aggressive behavior. YAP/TAZ signalling has been linked to pituitary development and stem cell regulation, with a preliminary study from our group revealing elevated levels and nuclear localization of YAP/TAZ in non-functioning PitNETs (NF-PitNETs). CTGF, a YAP/TAZ target gene, encodes a secreted factor involved in proliferation and angiogenesis, that has been implicated ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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